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Neonicotinoid insecticides implicated in honeybee colony collapse disorder {CCD}

Now new studies indicate that insecticides are playing a significant role.
The most recent studies have exposed a variety of insects to varying doses of neonicotinoid insecticides over long time periods – 12 months or more. Neonicotinoid insecticides are widely used worldwide; they work by acting on the central nervous system of the insect. The chemicals have little affinity for vertebrate nervous systems, so they are much less toxic to mammals and birds.
The researchers found that the total dose of insecticide required to kill the insect was smaller if administered over a longer time period (Ecotoxicology (2009) 18:343–354). In the case of honeybees, up to 6000 times less insecticide was required to kill them if it was administered in multiple tiny doses over a long time period.
According to Henk Tennekes, a researcher at Experimental Toxicology Services (ETS) in the Netherlands, these findings make perfect sense. “Start by considering a high exposure level,” he said. “It may cause an early effect, such as cancer or mortality. At a much lower exposure level you may get a late effect. However, as it turns out, in the latter case you need much less of the stuff (in total) to produce the effect.” Tennekes describes the findings in a forthcoming paper in Toxicology.
So how do these insecticides achieve such a powerful long-term effect? The answer lies in the way that they work. Neonicotinoids bind irreversibly to receptors in the central nervous system of insects. “An insect has a limited amount of such receptors,” explained Jeroen van der Sluijs, a scientist at Utrecht University in the Netherlands, who has also worked on the problem. “The damage is cumulative: with every exposure more receptors are blocked until the damage is so big that the insect cannot function anymore and dies.”
Right now it still isn’t possible to say if neonicotinoids are the sole cause of CCD in honeybees, but it seems likely that they play a significant role. “It explains the rapid increase in CCD since 2004, which coincides with the rapid growth in worldwide use of neonicotinoids – the most widely used class of insecticides,” said van der Sluijs.
Read more at environmentalresearchweb.org

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LONDON — Is British business fretting about the risks of the country drifting out of the European Union? Or does it crave a looser relationship with Continental allies, one free from meddlesome regulation?
The answer to that question remained unclear Monday after a newly formed group of business leaders argued for a renegotiation of Britain’s membership terms — echoing the policy of Prime Minister David Cameron, who in January promised voters a referendum on whether the country would remain in the Union.
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